|
KMID : 0352720110350010069
|
|
Journal of Ginseng Research
2011 Volume.35 No. 1 p.69 ~ p.79
|
|
|
Therapeutic Effects of Korean Red Ginseng Extract in Egyptian Patients with Chronic Liver Diseases
|
|
Abdel-Wahhab Mosaad A.
Gamil Khaled
El-Kady Ahmed A.
El-Nekeety Aziza A.
Naguib Khayria M.
|
|
|
Abstract
|
|
|
|
Hepatocellular carcinoma (HCC) is the fi fth most common malignancy in the world and complicates liver cirrhosis related to hepatitis C virus (HCV) in many cases. We evaluated the therapeutic effect of Korean red ginseng extract (KGE) in patients with chronic liver diseases. Thirty male and female patients with HCC and another thirty with liver cirrhosis were included. Each category was divided into two groups; the fi rst was used as control group, and received medical therapy only and the second group received the medical therapy supplemented with KGE capsules. The treated group with HCC received three KGE capsules/day (900 ㎎) while the treated group with HCV received two KGE capsules/day (600 ㎎) for 11 weeks along with their medical therapy. All patients were subjected to clinical examination and laboratory investigations, including liver function tests (at baseline, after 6 weeks of treatment and at the end of the study) and abdominal ultrasonography. Patients showing focal hepatic lesions were subjected to triphasic spiral abdominal computerized tomography and alpha-fetoprotein (AFP). HCV RNA was determined quantitatively by Roche for patients in the HCV group. Results showed that the medical therapy alone failed to normalize the liver enzymes or decrease the virus concentration. KGE administration induced a signifi cant improvement in liver function tests, decreased the tumor marker (AFP) levels, and decreased the viral titers in HCV patients. Thus, KGE demonstrated powerful therapeutic effects against HCV and liver cancer.
|
|
|
KEYWORD
|
|
|
Panax ginseng, Neoplasms, Egypt, Hepacivirus, Korean ginseng, Liver diseases
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|